The Healthy South Carolina Initiative (HSCI) is a statewide project currently funded through the Centers for Disease Control and Prevention’s Community Transformation Grant Program (CTG). The grant program is focused on decreasing death and disability from poor nutrition, physical inactivity, tobacco use, high cholesterol and hypertension.  Forty-one out of forty-six counties in South Carolina are uniting communities through the CTG to maximize health impacts through prevention, health risk reduction and partnership. We have accomplished a great deal, but there is much left to do. As we continue our work, my hope is that we will begin to see our efforts manifest in real reductions in health disparities, obesity and chronic conditions. If we are to improve health and well-being, we must support health behavior change at the individual, community, institutional and public policy levels. Grantees are engaging local communities, working to increase access to healthy foods, creating active communities and supporting tobacco-free environments. Both our state and local partners have contributed to our accomplishments by building a strong infrastructure to support the overall implementation of the CTG in South Carolina. A special “thank you” is due to all our HSCI partners and advocates for the work you are doing to implement evidence-based environmental and system change strategies directed towards community health improvement. We are excited to showcase HSCI and ask that you continue to actively support us in transforming the health of our communities.